what treatment do i do next ?

I went into remission back in 1989 and it come back in 2007. I've had treatments from IVIG,Rix, Pred, N-plate,cellcept, had assoc spleen removed and nothing seem to work, the doctor ween me off pred while on Promacta. But while I was on Predisone and Promacta my platelet shot up to 241 so I was weened of the predisone and lowered my promacta to every other day. I've watch my platelets slowly dropped to 65 two weeks ago so my doctor told me to increase my promacta to 25 mg every day. Today count was 35. I have to go see her on Wed.for my check up and see what the next step is. Nothing seems to work and I'm getting tried of being tried. I went and maybe still going through withdraws from the predisone, my body hurts and I'm containing fluids when I wake up in the morning my feet and hands are swellen, have pain that feels like its coming from the bones. I don't know what to think or do anymore.

DeeDee - I wouldn't say that Promacta isn't working. Maybe you just need to raise the dose again. Is that possible?

How long ago did you stop Prednisone?

I'd think that 35 is an okay count for Promacta. I aim at 30 to 50 with Nplate. I don't want higher although I often get it. Funny now that I want low counts I can't keep them low.

The doctor up my promacta to 50 mg every day, we'll see what happens. I stopped my predisone in January but still hurting. My electro lights are out of wack but have to go the doctors tomorrow. Thanks for the input it really helps to know that you have support out there and that your not alone. Let you know what happens :ohmy:

In one sentence you say "nothing seems to work", yet you have a 35k count with only 25mg/day dose of Promacta?
I would hazard a guess and say that Promacta IS working.
Remember, Promacta is designed to keep one "around 50k" (safe), not boost platelets into the 'normal range'.
I take 50mg/day and my counts run between 40k and 50k.

It can take a few months to get rid of the withdrawal. Hang in there.

Which electrolytes are affected? That can cause some serious problems/symptoms too if low enough.